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. 2007 Dec;28(34):5044-8.
doi: 10.1016/j.biomaterials.2007.06.035. Epub 2007 Jul 23.

Wear particles, periprosthetic osteolysis and the immune system

Stuart B Goodman  1
Affiliations

Wear particles, periprosthetic osteolysis and the immune system

Stuart B Goodman. Biomaterials. 2007 Dec.

Abstract

The immune system modulates many key biological processes in humans. However, the exact role of the immune system in particle-associated periprosthetic osteolysis is controversial. Human tissue retrieval studies, in vivo and in vitro experiments suggest that the immune response to polymer particles is non-specific and macrophage-mediated. Lymphocytes may modulate this response. However direct lymphocyte activation by polymer particle-protein complexes seems unlikely. However, metallic byproducts may complex with serum proteins and lead to a Type IV, lymphocyte-mediated immune reaction. In predisposed individuals, this reaction may rarely lead to persistent painful joint effusions, necessitating debridement and excision of the bearing surfaces of the prosthesis. In these patients, retrieved periprosthetic tissues exhibit histological evidence of perivascular lymphocytic cuffing. These findings are worrisome, given the fact that increasing numbers of metal-on-metal joint implants are being implanted in younger more active individuals worldwide.

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References

    1. Willert HG, Semlitsch M. Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res. 1977;11:157–164. - PubMed
    1. Willert H-G, Buchorn G, Buchorn U, Semlisch M. Implant Retrieval Conference; Gaithersberg MD. May 1-2, 1980.
    1. Schmalzried TP, Kwong LM, Jasty M, et al. The mechanism of loosening of cemented acetabular components in total hip arthroplasty. Analysis of specimens retrieved at autopsy. Clin Orthop. 1992;274:60–78. - PubMed
    1. Kadoya Y, Revell PA, al-Saffar N, Kobayashi A, Scott G, Freeman MA. Bone formation and bone resorption in failed total joint arthroplasties: histomorphometric analysis with histochemical and immunohistochemical technique. J Orthop Res. 1996 May;14(3):473–82. - PubMed
    1. Goodman SB, Huie P, Song Y, Schurman D, Maloney W, Woolson S, Sibley R. Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. J Bone Joint Surg Br. 1998 May;80(3):531–9. - PubMed

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