Mechanisms that mediate stem cell self-renewal and differentiation
- PMID: 17647265
- DOI: 10.1002/jcb.21460
Mechanisms that mediate stem cell self-renewal and differentiation
Abstract
Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells.
Copyright 2007 Wiley-Liss, Inc.
Similar articles
-
A dive into the stem cells world.Panminerva Med. 2009 Mar;51(1):1-3. Panminerva Med. 2009. PMID: 19352304 No abstract available.
-
Stem cells: current challenges and future promise.Dev Dyn. 2007 Dec;236(12):3193-8. doi: 10.1002/dvdy.21203. Dev Dyn. 2007. PMID: 17584855
-
Nuclear reprogramming by human embryonic stem cells.Cell. 2005 Sep 9;122(5):653-4. doi: 10.1016/j.cell.2005.08.023. Cell. 2005. PMID: 16143098 Review.
-
Human embryonic stem cells: multilineage differentiation and mechanisms of self-renewal.Arch Med Res. 2003 Nov-Dec;34(6):558-64. doi: 10.1016/j.arcmed.2003.08.006. Arch Med Res. 2003. PMID: 14734096 Review.
-
[Progress on embryonic stem cells for the treatment of myocardial infarction].Sheng Li Ke Xue Jin Zhan. 2004 Jul;35(3):205-9. Sheng Li Ke Xue Jin Zhan. 2004. PMID: 15469088 Review. Chinese.
Cited by
-
The effects of β-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination.Exp Biol Med (Maywood). 2022 Nov;247(21):1956-1967. doi: 10.1177/15353702221119792. Epub 2022 Sep 12. Exp Biol Med (Maywood). 2022. PMID: 36112854 Free PMC article.
-
Islet-1 induces the differentiation of mesenchymal stem cells into cardiomyocyte-like cells through the regulation of Gcn5 and DNMT-1.Mol Med Rep. 2017 May;15(5):2511-2520. doi: 10.3892/mmr.2017.6343. Epub 2017 Mar 16. Mol Med Rep. 2017. PMID: 28447752 Free PMC article.
-
The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.Genes Dis. 2023 Jul 22;11(3):101026. doi: 10.1016/j.gendis.2023.04.042. eCollection 2024 May. Genes Dis. 2023. PMID: 38292186 Free PMC article. Review.
-
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate.Cell Mol Life Sci. 2024 Jan 12;81(1):26. doi: 10.1007/s00018-023-05070-6. Cell Mol Life Sci. 2024. PMID: 38212548 Free PMC article. Review.
-
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.Hum Mol Genet. 2012 May 1;21(9):2054-67. doi: 10.1093/hmg/dds023. Epub 2012 Jan 27. Hum Mol Genet. 2012. PMID: 22286172 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources