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Review
. 2008 Feb 15;103(3):709-18.
doi: 10.1002/jcb.21460.

Mechanisms that mediate stem cell self-renewal and differentiation

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Review

Mechanisms that mediate stem cell self-renewal and differentiation

Haojian Zhang et al. J Cell Biochem. .

Abstract

Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells.

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