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. 2007 Jul-Aug;27(4A):1901-5.

Tumor markers in patients with relapse of colorectal carcinoma

Ludmila Lipská  1 , Vladimir Visokai, Miroslav Levý, Sárka Svobodová, Stanislav Kormunda, Jindrich Fínek
Affiliations
  • PMID: 17649792
Free article

Tumor markers in patients with relapse of colorectal carcinoma

Ludmila Lipská et al. Anticancer Res. 2007 Jul-Aug.
Free article

Abstract

Aim: To evaluate CEA and CA19-9 in a long-term follow-up after radical surgery for colorectal cancer.

Patients and methods: A total of 1,090 patients were operated on for colorectal cancer, 716 patients underwent R0 resection, 631 patients were under further surveillance, relapse was diagnosed in 122 patients (20%), 74 patients were indicated for reoperation The resectability of the relapse was 35%. An AxSYM instrument (Abbott) was used for analysis.

Results: At the time of relapse both markers were normal in 31% of the patients. When relapse was diagnosed, in patients with normal preoperative levels, CEA and CA19-9 were below cut-off in 48% and 79%, respectively, and in those with primary elevation, they were again elevated in 78% and 64%, respectively.

Conclusion: The surveillance based only on CEA and/or CA19-9 was cost-effective, but failed to disclose 1/3 of patients suffering from relapse; these markers must be combined with liver and chest imaging methods and colonoscopy.

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