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Review
. 1991 Dec 1;47(11-12):1186-93.
doi: 10.1007/BF01918382.

Fifty years of amanitin

T Wieland  1 , H Faulstich
Affiliations
Review

Fifty years of amanitin

T Wieland et al. Experientia. .

Abstract

Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.

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