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. 2007 Sep 3;97(5):695-9.
doi: 10.1038/sj.bjc.6603908. Epub 2007 Jul 24.

A study of soft tissue sarcomas after childhood cancer in Britain

H C Jenkinson  1 , D L Winter, H B Marsden, M A Stovall, M C G Stevens, C A Stiller, M M Hawkins
Affiliations

A study of soft tissue sarcomas after childhood cancer in Britain

H C Jenkinson et al. Br J Cancer. .

Abstract

Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P<0.001). This effect remained significant in a multivariate model. The adjusted risk in patients exposed to RT doses of over 3000 cGy was over 50 times the risk in the unexposed. There was evidence of a dose-response effect with exposure to alkylating agents, the risk increasing substantially with increasing cumulative dose (P=0.05). This effect remained after adjusting for the effect of radiation exposure.

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