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Review
. 2007 Jul-Aug;158(6):487-93.
doi: 10.1016/j.resmic.2007.05.001. Epub 2007 May 21.

The two-faced role of cad genes in the virulence of pathogenic Escherichia coli

Gianni Prosseda  1 , Maria Carmela Latella, Marialuisa Barbagallo, Mauro Nicoletti, Rasha Al Kassas, Mariassunta Casalino, Bianca Colonna
Affiliations
Free article
Review

The two-faced role of cad genes in the virulence of pathogenic Escherichia coli

Gianni Prosseda et al. Res Microbiol. 2007 Jul-Aug.
Free article

Abstract

In enterobacteria, acid stress induces expression of the cad system which is involved in maintaining intracellular pH at levels compatible with cell survival. Despite its crucial role, the cad operon is silenced in Shigella and in other pathogenic Escherichia coli. In the present review, we will address the question of why and how the cad locus has been sacrificed for the sake of optimal expression of virulence traits.

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