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Case Reports
. 2007 Jul 15;176(2):169-71.
doi: 10.1016/j.cancergencyto.2006.12.011.

Monosomy 7 in t(9;22)-negative cells during nilotinib therapy in an imatinib-resistant chronic myeloid leukemia case

Amer Zeidan, Surabhi Kakati, Barbara Anderson, Maurice Barcos, Meir Wetzler
Case Reports

Monosomy 7 in t(9;22)-negative cells during nilotinib therapy in an imatinib-resistant chronic myeloid leukemia case

Amer Zeidan et al. Cancer Genet Cytogenet. .
No abstract available

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Figures

Figure 1
Figure 1
Cytogenetic and morphological analyses of an imatinib-resistant CML patient during nilotinib therapy. A, percentages of 46,XX, monosomy 7 and t(9;22) cells; B, marrow biopsy from August 2006 representing advanced granulopoiesis and erythropoiesis and several dysplastic megakaryocytes with hypolobated or bizarre elongated hyperchromatic nuclei (Giemsa stained section, x25); C-E, different areas from the bone marrow biopsy from September 2006; C, advanced granulopoiesis and erythropoiesis and syncytial dysplastic megakaryopoiesis with hypolobated or vesicular nuclei (Giemsa stained section, x25); D, dysplastic megakaryocyte with large hypolobated nucleus with reticular chromatin (Wright-Giemsa stained imprint, x250); E, dysplastic mononuclear and binuclear pronormoblasts with prominent nucleoli (Wright-Giemsa stained smear, x100).
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