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Comment

. 2007 Sep 1;583(Pt 2):415-6.

doi: 10.1113/jphysiol.2007.140764. Epub 2007 Jul 26.

Going to cAMP just got more complicated

Donald M Bers¹

Affiliations

PMID: 17656427
PMCID: PMC2277018
DOI: 10.1113/jphysiol.2007.140764

Comment

Going to cAMP just got more complicated

Donald M Bers. J Physiol. 2007.

. 2007 Sep 1;583(Pt 2):415-6.

doi: 10.1113/jphysiol.2007.140764. Epub 2007 Jul 26.

Author

Donald M Bers¹

Affiliation

¹ Dpartment of Physiology, Loyola University, Chicago Maywood, IL, USA. dbers@lumc.edu

PMID: 17656427
PMCID: PMC2277018
DOI: 10.1113/jphysiol.2007.140764

No abstract available

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Figures

Figure 1
Activation of Epac by cAMP and activation of CaMKII-dependent phosphorylation of the RyR Broken lines and question marks indicate aspects where the possible pathway requires further tests. Abbreviations are as in text except: I_Na is Na⁺ current, α_s, β and γ are subunits of the G_s-protein, AC is adenylate cyclase, PLB is phospholamban, ATP is SR Ca²⁺-ATPase, CaM is calmodulin, and C and R are the catalytic and regulatory subunits of PKA.

See this image and copyright information in PMC

Comment in

EPAC regulation of cardiac EC coupling.
Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. Smrcka AV, et al. J Physiol. 2007 Nov 1;584(Pt 3):1029-31. doi: 10.1113/jphysiol.2007.145037. Epub 2007 Sep 20. J Physiol. 2007. PMID: 17884917 Free PMC article. No abstract available.

Comment on

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.
Pereira L, Métrich M, Fernández-Velasco M, Lucas A, Leroy J, Perrier R, Morel E, Fischmeister R, Richard S, Bénitah JP, Lezoualc'h F, Gómez AM. Pereira L, et al. J Physiol. 2007 Sep 1;583(Pt 2):685-94. doi: 10.1113/jphysiol.2007.133066. Epub 2007 Jun 28. J Physiol. 2007. PMID: 17599964 Free PMC article.

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References

1. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. 2. Dordrecht, the Netherlands: Kluwer Academic Press; 2001.
1. Bos JL. Trends Biochem Sci. 2006;31:680–686. - PubMed
1. Curran J, Ríos E, Bers DM, Shannon TR. Circ Res. 2007;100:391–398. - PubMed
1. Dodge-Kafka KL, Kapiloff MS. Eur J Cell Biol. 2006;85:593–602. - PubMed
1. McConnachie G, Langeberg LK, Scott JD. Trends Mol Med. 2006;12:317–323. - PubMed

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