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Comment
. 2007 Sep 1;583(Pt 2):415-6.
doi: 10.1113/jphysiol.2007.140764. Epub 2007 Jul 26.

Going to cAMP just got more complicated

Donald M Bers  1
Affiliations
Comment

Going to cAMP just got more complicated

Donald M Bers. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
Activation of Epac by cAMP and activation of CaMKII-dependent phosphorylation of the RyR Broken lines and question marks indicate aspects where the possible pathway requires further tests. Abbreviations are as in text except: INa is Na+ current, αs, β and γ are subunits of the Gs-protein, AC is adenylate cyclase, PLB is phospholamban, ATP is SR Ca2+-ATPase, CaM is calmodulin, and C and R are the catalytic and regulatory subunits of PKA.
See this image and copyright information in PMC

Comment in

  • EPAC regulation of cardiac EC coupling.
    Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. Smrcka AV, et al. J Physiol. 2007 Nov 1;584(Pt 3):1029-31. doi: 10.1113/jphysiol.2007.145037. Epub 2007 Sep 20. J Physiol. 2007. PMID: 17884917 Free PMC article. No abstract available.

Comment on

References

    1. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. 2. Dordrecht, the Netherlands: Kluwer Academic Press; 2001.
    1. Bos JL. Trends Biochem Sci. 2006;31:680–686. - PubMed
    1. Curran J, Ríos E, Bers DM, Shannon TR. Circ Res. 2007;100:391–398. - PubMed
    1. Dodge-Kafka KL, Kapiloff MS. Eur J Cell Biol. 2006;85:593–602. - PubMed
    1. McConnachie G, Langeberg LK, Scott JD. Trends Mol Med. 2006;12:317–323. - PubMed

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