Eroding the resistance of Duffy negativity to invasion by Plasmodium vivax?
- PMID: 17658565
- DOI: 10.1016/j.trstmh.2007.05.007
Eroding the resistance of Duffy negativity to invasion by Plasmodium vivax?
Abstract
Individuals possessing red cells negative for the Duffy blood group antigen are said to possess absolute resistance to infection by the malarial parasite Plasmodium vivax. Now in this issue of Transactions, initial evidence is presented from the Brazilian Amazon to suggest that P. vivax is being transmitted amongst Duffy-negative individuals. This supports data from East Africa where the same phenomenon has been observed. Thus the emerging picture is that P. vivax in both South America and in Africa is now evolving pathways other than Duffy to enter red cells.
Comment on
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Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?Trans R Soc Trop Med Hyg. 2007 Oct;101(10):1042-4. doi: 10.1016/j.trstmh.2007.04.011. Epub 2007 Jun 29. Trans R Soc Trop Med Hyg. 2007. PMID: 17604067
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