Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Aug;25(3):611-67, v.
doi: 10.1016/j.ncl.2007.03.009.

Genetics of Alzheimer's disease: a centennial review

Nilüfer Ertekin-Taner  1
Affiliations
Review

Genetics of Alzheimer's disease: a centennial review

Nilüfer Ertekin-Taner. Neurol Clin. 2007 Aug.

Abstract

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1, PSEN2) and one late-onset AD susceptibility gene, apolipoprotein E (APOE), exist with ample biologic, genetic, and epidemiologic data. Evidence suggests a significant genetic component underlying AD that is not explained by the known genetic risk factors. This article summarizes the evidence for the genetic component in AD and the identification of the early-onset familial AD genes and APOE, and examines the current state of knowledge about additional AD susceptibility loci and alleles. The future directions for genetic research in AD as a common and complex condition are also discussed.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci. 2003;26:81–104. - PubMed
    1. Rice DP, Fillit HM, Max W, Knopman DS, Lloyd JR, Duttagupta S. Prevalence, costs, and treatment of Alzheimer’s disease and related dementia: a managed care perspective. Am J Manag Care. 2001 Aug;7(8):809–818. - PubMed
    1. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset. Am J Public Health. 1998 Sep;88(9):1337–1342. - PMC - PubMed
    1. Borenstein AR, Copenhaver CI, Mortimer JA. Early-life risk factors for Alzheimer disease. Alzheimer Dis Assoc Disord. 2006 Jan–Mar;20(1):63–72. - PubMed
    1. Whalley LJ, Dick FD, McNeill G. A life-course approach to the aetiology of late-onset dementias. Lancet Neurol. 2006 Jan;5(1):87–96. - PubMed

Substances