Negative signals from FcepsilonRI engagement attenuate mast cell functions
- PMID: 17659377
- DOI: 10.1007/s00005-007-0028-4
Negative signals from FcepsilonRI engagement attenuate mast cell functions
Abstract
Mast cells have long been recognized as the critical tissue-based effector cells in IgE-mediated allergic diseases. Ligation of the high-affinity receptor for IgE (FcepsilonRI), constitutively expressed on mast cells, promotes cell activation and immediate release and production of pro-inflammatory mediators. Besides these positive signals, FcepsilonRI aggregation has recently been understood to generate negative intracellular signals capable of limiting mast cell functional responses. This review is aimed at providing a summary of the mechanisms through which FcepsilonRI engagement can generate negative signals and regulate mast-cell function. Similar mechanisms are employed by other receptors expressed by immune cells, such as T cell and B cell receptors, pointing to a general concept in negative immunoreceptor signaling.
Similar articles
-
Regulation of allergy by Fc receptors.Curr Opin Immunol. 2005 Dec;17(6):662-9. doi: 10.1016/j.coi.2005.09.012. Epub 2005 Oct 7. Curr Opin Immunol. 2005. PMID: 16214316 Review.
-
Human mast cell line-1 (HMC-1) cells transfected with FcεRIα are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production.Int Immunopharmacol. 2011 Aug;11(8):1002-11. doi: 10.1016/j.intimp.2011.02.017. Epub 2011 Feb 26. Int Immunopharmacol. 2011. PMID: 21356342
-
Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation.Arch Immunol Ther Exp (Warsz). 2008 Nov-Dec;56(6):385-99. doi: 10.1007/s00005-008-0041-2. Epub 2008 Dec 1. Arch Immunol Ther Exp (Warsz). 2008. PMID: 19082920 Review.
-
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.Immunol Lett. 2007 Nov 15;113(2):59-69. doi: 10.1016/j.imlet.2007.08.007. Epub 2007 Sep 18. Immunol Lett. 2007. PMID: 17919738 Free PMC article. Review.
-
Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation.Immunol Rev. 2009 Nov;232(1):99-114. doi: 10.1111/j.1600-065X.2009.00825.x. Immunol Rev. 2009. PMID: 19909359 Review.
Cited by
-
Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ.Mol Biol Cell. 2019 Aug 1;30(17):2331-2347. doi: 10.1091/mbc.E18-11-0722. Epub 2019 Jun 19. Mol Biol Cell. 2019. PMID: 31216232 Free PMC article.
-
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.J Exp Med. 2009 Jan 16;206(1):195-207. doi: 10.1084/jem.20081140. Epub 2009 Jan 5. J Exp Med. 2009. PMID: 19124655 Free PMC article.
-
Two-allergen model reveals complex relationship between IgE crosslinking and degranulation.Chem Biol. 2014 Nov 20;21(11):1445-51. doi: 10.1016/j.chembiol.2014.08.019. Epub 2014 Oct 9. Chem Biol. 2014. PMID: 25308278 Free PMC article.
-
Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator.Mol Immunol. 2009 Jun;46(10):2133-9. doi: 10.1016/j.molimm.2009.03.013. Epub 2009 Apr 15. Mol Immunol. 2009. PMID: 19371953 Free PMC article.
-
Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN.Cells. 2023 Feb 1;12(3):469. doi: 10.3390/cells12030469. Cells. 2023. PMID: 36766811 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources