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Review
. 2007 Jul-Aug;55(4):219-29.
doi: 10.1007/s00005-007-0028-4. Epub 2007 Jul 23.

Negative signals from FcepsilonRI engagement attenuate mast cell functions

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Free article
Review

Negative signals from FcepsilonRI engagement attenuate mast cell functions

Rosa Molfetta et al. Arch Immunol Ther Exp (Warsz). 2007 Jul-Aug.
Free article

Abstract

Mast cells have long been recognized as the critical tissue-based effector cells in IgE-mediated allergic diseases. Ligation of the high-affinity receptor for IgE (FcepsilonRI), constitutively expressed on mast cells, promotes cell activation and immediate release and production of pro-inflammatory mediators. Besides these positive signals, FcepsilonRI aggregation has recently been understood to generate negative intracellular signals capable of limiting mast cell functional responses. This review is aimed at providing a summary of the mechanisms through which FcepsilonRI engagement can generate negative signals and regulate mast-cell function. Similar mechanisms are employed by other receptors expressed by immune cells, such as T cell and B cell receptors, pointing to a general concept in negative immunoreceptor signaling.

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