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Review
. 2007 Sep;55(12):1272-1279.
doi: 10.1002/glia.20360.

Compartmentalization of brain energy metabolism between glia and neurons: insights from mathematical modeling

Agnès Aubert  1 , Robert Costalat  2
Affiliations
Review

Compartmentalization of brain energy metabolism between glia and neurons: insights from mathematical modeling

Agnès Aubert et al. Glia. 2007 Sep.

Abstract

We review the contribution of mathematical modeling of metabolic pathways to the study of the compartmentalization of brain energy metabolism between neurons and glia. We especially focus on the role of lactate in the relationship between glia and neurons and the possible presence of an astrocyte-neuron lactate shuttle (ANLS). We first discuss models of glucose, pyruvate, and lactate kinetics, which are relevant to neuron-glia interactions. We then review models of compartmentalized energy metabolism, which deal with the concepts of 'red' and 'white' stimulations, and the ANLS hypothesis. We next show the contribution of a study of model robustness to the debate about the potential role of lactate in metabolic interactions between glia and neurons. Finally, we discuss the possible implications of modeling for further experimental studies.

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References

REFERENCES

    1. Attwell D, Laughlin SB. 2001. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21: 1133-1145.
    1. Aubert A, Costalat R. 2002. A model of the coupling between brain electrical activity, metabolism and hemodynamics: Application to the interpretation of functional neuroimaging. Neuroimage 17: 1162-1181.
    1. Aubert A, Costalat R. 2005. Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism. J Cereb Blood Flow Metab 25: 1476-1490.
    1. Aubert A, Costalat R, Magistretti PJ, Pellerin L. 2005. Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. Proc Natl Acad Sci USA 102: 16448-16453.
    1. Chih C-P, Roberts ELJr. 2003. Energy substrates for neurons during neural activity: A critical review of the astrocyte-neuron lactate shuttle hypothesis. J Cereb Blood Flow Metab 23: 1263-1281.

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