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Case Reports
. 1991 Oct;18(10):1621-2.

Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis

W B Graninger  1 , W Hassfeld, B B Pesau, K P Machold, C C Zielinski, J S Smolen
Affiliations
  • PMID: 1765991
Case Reports

Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis

W B Graninger et al. J Rheumatol. 1991 Oct.

Abstract

The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis. In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive. We assume that rIFN-gamma induced the de novo development of SLE in our patient.

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