doi: 10.1093/bioinformatics/btm368.
Epub 2007 Jul 27.
BLISS 2.0: a web-based tool for predicting conserved regulatory modules in distantly-related orthologous sequences
Affiliations
- PMID: 17660203
- PMCID: PMC2584781
- DOI: 10.1093/bioinformatics/btm368
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BLISS 2.0: a web-based tool for predicting conserved regulatory modules in distantly-related orthologous sequences
Bioinformatics.
.
Abstract
BLISS 2.0 is a web-based application for identifying conserved regulatory modules in distantly related orthologous sequences. Unlike existing approaches, it performs the cross-genome comparison at the binding site level. Experimental results on simulated and real world data indicate that BLISS 2.0 can identify conserved regulatory modules from sequences with little overall similarity at the DNA sequence level.
Availability: http://www.blisstool.org/
Figures
Web interface of BLISS 2.0. Output of BLISS2_scores, which indicates the degree of conservation at the binding site level between the two sequences. The two axes correspond to the two inputted sequences. The color reflects the BLISS2_score value at corresponding positions.
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