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Case Reports
. 2008 Feb;27(2):249-51.
doi: 10.1007/s10067-007-0704-0. Epub 2007 Jul 28.

A 57-year-old man who developed arthritis during R-CHOP chemotherapy for non-Hodgkin lymphoma

F H Swaneveld  1 , R M van Vugt, J P de Boer, B A C Dijkmans, W F Lems
Affiliations
Case Reports

A 57-year-old man who developed arthritis during R-CHOP chemotherapy for non-Hodgkin lymphoma

F H Swaneveld et al. Clin Rheumatol. 2008 Feb.

Abstract

Rituximab is a chimeric human-mouse anti-CD20 monoclonal antibody, which is used in the treatment of both B-cell lymphomas and rheumatic diseases. We describe a case of a previously healthy 57-year-old man developing arthritis while being treated with rituximab-CHOP chemotherapy (R-CHOP) for a non-Hodgkin lymphoma. The remittant arthritis developed at successively shorter time-intervals after R-CHOP administration and only improved after rituximab was removed from the chemotherapy schedule, suggesting a rituximab-related phenomenon, as extensive diagnostic testing ruled out any other diagnosis.

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