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Comment
. 2007 Jul 27;130(2):211-3.
doi: 10.1016/j.cell.2007.07.002.

Mitochondrial DNA transcription: regulating the power supply

Robert W Taylor  1 , Douglass M Turnbull
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Free article
Comment

Mitochondrial DNA transcription: regulating the power supply

Robert W Taylor et al. Cell. .
Free article

Abstract

In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.

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  • MTERF3 is a negative regulator of mammalian mtDNA transcription.
    Park CB, Asin-Cayuela J, Cámara Y, Shi Y, Pellegrini M, Gaspari M, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Falkenberg M, Gustafsson CM, Larsson NG. Park CB, et al. Cell. 2007 Jul 27;130(2):273-85. doi: 10.1016/j.cell.2007.05.046. Cell. 2007. PMID: 17662942

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