ATP synthase: motoring to the finish line
- PMID: 17662937
- DOI: 10.1016/j.cell.2007.07.004
ATP synthase: motoring to the finish line
Abstract
Protonmotive force produced by the electron transport chain is harnessed by the rotary molecular nanomotor ATP synthase to generate ATP. In this issue of Cell, Adachi et al. (2007), in a dazzling display of technical sophistication, now disentangle the coupling between the mechanical force generated by rotation of the ATP synthase subunits and the chemical reactions that occur simultaneously at the enzyme's three catalytic sites.
Comment on
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Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.Cell. 2007 Jul 27;130(2):309-21. doi: 10.1016/j.cell.2007.05.020. Cell. 2007. PMID: 17662945
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