Marine cytotoxic macrolides haterumalides and biselides, and related natural products
- PMID: 17663448
- DOI: 10.1002/tcr.20119
Marine cytotoxic macrolides haterumalides and biselides, and related natural products
Abstract
Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.
Similar articles
-
Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B.Chemistry. 2011 Jan 10;17(2):675-88. doi: 10.1002/chem.201001682. Epub 2010 Nov 9. Chemistry. 2011. PMID: 21207589
-
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.Chem Commun (Camb). 2008 Oct 14;(38):4628-30. doi: 10.1039/b811575c. Epub 2008 Aug 28. Chem Commun (Camb). 2008. PMID: 18815706
-
Cytotoxic macrolides from a new species of the deep-water marine sponge Leiodermatium.J Org Chem. 2006 Sep 15;71(19):7245-51. doi: 10.1021/jo060958y. J Org Chem. 2006. PMID: 16958517
-
Actin-binding marine macrolides: total synthesis and biological importance.Angew Chem Int Ed Engl. 2002 Dec 16;41(24):4632-53. doi: 10.1002/anie.200290057. Angew Chem Int Ed Engl. 2002. PMID: 12481316 Review.
-
Marine spongean cytotoxins.J Nat Toxins. 1999 Jun;8(2):249-58. J Nat Toxins. 1999. PMID: 10410335 Review.
Cited by
-
Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization.J Am Chem Soc. 2008 Sep 17;130(37):12228-9. doi: 10.1021/ja8043695. Epub 2008 Aug 23. J Am Chem Soc. 2008. PMID: 18722441 Free PMC article.
-
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11644-11648. doi: 10.1002/anie.201805363. Epub 2018 Jul 31. Angew Chem Int Ed Engl. 2018. PMID: 29898240 Free PMC article.
-
Total synthesis of biselide A.Chem Sci. 2021 Mar 12;12(15):5534-5543. doi: 10.1039/d0sc06223e. Chem Sci. 2021. PMID: 34168790 Free PMC article.
-
Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides.Nat Commun. 2024 Mar 21;15(1):2534. doi: 10.1038/s41467-024-46721-x. Nat Commun. 2024. PMID: 38514617 Free PMC article.
-
The Tetrahydrofuran Motif in Polyketide Marine Drugs.Mar Drugs. 2022 Feb 3;20(2):120. doi: 10.3390/md20020120. Mar Drugs. 2022. PMID: 35200649 Free PMC article. Review.