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. 2007 Oct;51(10):3731-3.
doi: 10.1128/AAC.00101-07. Epub 2007 Jul 30.

Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus

Thomas P Lodise Jr  1 , Peggy S McKinnon, Donald P Levine, Michael J Rybak
Affiliations

Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus

Thomas P Lodise Jr et al. Antimicrob Agents Chemother. 2007 Oct.

Abstract

This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

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References

    1. Bodi, M., C. Ardanuy, and J. Rello. 2001. Impact of gram-positive resistance on outcome of nosocomial pneumonia. Crit. Care Med. 29:N82-N86. - PubMed
    1. Cantoni, L., M. P. Glauser, and J. Bille. 1990. Comparative efficacy of daptomycin, vancomycin, and cloxacillin for the treatment of Staphylococcus aureus endocarditis in rats and role of test conditions in this determination. Antimicrob. Agents Chemother. 34:2348-2353. - PMC - PubMed
    1. Chambers, H. F., R. T. Miller, and M. D. Newman. 1988. Right-sided Staphylococcus aureus endocarditis in intravenous drug abusers: two-week combination therapy. Ann. Intern. Med. 109:619-624. - PubMed
    1. Chang, F. Y., J. E. Peacock, Jr., D. M. Musher, P. Triplett, B. B. MacDonald, J. M. Mylotte, A. O'Donnell, M. M. Wagener, and V. L. Yu. 2003. Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study. Medicine (Baltimore) 82:333-339. - PubMed
    1. Fortun, J., E. Navas, J. Martinez-Beltran, J. Perez-Molina, P. Martin-Davila, A. Guerrero, and S. Moreno. 2001. Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers: cloxacillin versus glycopeptides in combination with gentamicin. Clin. Infect. Dis. 33:120-125. - PubMed