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. 2007 Oct;51(10):3731-3.
doi: 10.1128/AAC.00101-07. Epub 2007 Jul 30.

Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus

Thomas P Lodise Jr  1 , Peggy S McKinnon, Donald P Levine, Michael J Rybak
Affiliations

Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus

Thomas P Lodise Jr et al. Antimicrob Agents Chemother. 2007 Oct.

Abstract

This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

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