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Randomized Controlled Trial
. 2007 Aug:191:131-9.
doi: 10.1192/bjp.bp.105.017020.

Long-acting injectable risperidone v. olanzapine tablets for schizophrenia or schizoaffective disorder. Randomised, controlled, open-label study

Nicholas A Keks  1 , Michael Ingham, Akbar Khan, Keith Karcher
Affiliations
Randomized Controlled Trial

Long-acting injectable risperidone v. olanzapine tablets for schizophrenia or schizoaffective disorder. Randomised, controlled, open-label study

Nicholas A Keks et al. Br J Psychiatry. 2007 Aug.

Abstract

Background: The efficacy and safety of long-acting injectable risperidone have not been compared with those of an oral atypical antipsychotic.

Aims: To compare long-acting risperidone and oral olanzapine in 377 patients with DSM-IV schizophrenia or schizoaffective disorder.

Method: Patients were randomised to receive long-acting risperidone (25 mg or 50 mg every 14 days) or olanzapine (5-20 mg/day).

Results: In the 13-week phase, long-acting risperidone was at least as effective as (not inferior to) oral olanzapine. In the 12-month phase, significant improvements in the Positive and Negative Syndrome Scale (PANSS) total and factor scores from baseline to month 12 and end-point were seen in both groups of patients. Few patients discontinued treatment because of an adverse event.

Conclusions: Both treatments were efficacious and well tolerated.

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