Effect of aging on wound healing: current concepts
- PMID: 17667088
- DOI: 10.1097/01.WON.0000281658.71072.e6
Effect of aging on wound healing: current concepts
Abstract
The population is aging, and advanced age is commonly identified as a risk factor for delayed wound healing. Therefore, it is important for WOC nurses to be knowledgeable about how aging affects the wound healing and repair process, and strategies they can use to promote healing in the elderly population. Impaired wound healing in the aged is due partly to comorbidities common among the elderly, but evidence also suggests that inherent differences in cellular structure and function may impair tissue repair and regeneration as well. This article will address the effect of aging on wound healing, with a particular focus on processes of cellular senescence and related factors hypothesized to result in slowed or impaired wound healing in the elderly.
Similar articles
-
Aging and wound healing.World J Surg. 2004 Mar;28(3):321-6. doi: 10.1007/s00268-003-7397-6. Epub 2004 Feb 17. World J Surg. 2004. PMID: 14961191 Review.
-
Wound healing and aging.Dermatol Clin. 1993 Oct;11(4):749-57. Dermatol Clin. 1993. PMID: 8222358 Review.
-
The hormonal regulation of cutaneous wound healing.Clin Dermatol. 2007 Jan-Feb;25(1):56-62. doi: 10.1016/j.clindermatol.2006.09.012. Clin Dermatol. 2007. PMID: 17276202 Review.
-
Wound healing and the aged patient.Nurs Clin North Am. 1990 Mar;25(1):263-77. Nurs Clin North Am. 1990. PMID: 2179892 Review.
-
Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens.Climacteric. 2007 Aug;10(4):276-88. doi: 10.1080/13697130701456630. Climacteric. 2007. PMID: 17653954 Review.
Cited by
-
Insight into Factors Influencing Wound Healing Using Phosphorylated Cellulose-Filled-Chitosan Nanocomposite Films.Int J Mol Sci. 2021 Oct 21;22(21):11386. doi: 10.3390/ijms222111386. Int J Mol Sci. 2021. PMID: 34768816 Free PMC article.
-
Injury rates and injury risk factors among Federal Bureau of Investigation new agent trainees.BMC Public Health. 2011 Dec 13;11:920. doi: 10.1186/1471-2458-11-920. BMC Public Health. 2011. PMID: 22166096 Free PMC article.
-
The transcriptional landscape of age in human peripheral blood.Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570. Nat Commun. 2015. PMID: 26490707 Free PMC article.
-
Chronic wounds treated with cold atmospheric plasmajet versus best practice wound dressings: a multicenter, randomized, non-inferiority trial.Sci Rep. 2022 Mar 7;12(1):3645. doi: 10.1038/s41598-022-07333-x. Sci Rep. 2022. PMID: 35256635 Free PMC article. Clinical Trial.
-
Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice.Clin Transl Med. 2024 May;14(5):e1660. doi: 10.1002/ctm2.1660. Clin Transl Med. 2024. PMID: 38764260 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical