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. 2007 Sep 3;97(5):605-11.
doi: 10.1038/sj.bjc.6603898. Epub 2007 Jul 31.

The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients

J K Chan  1 , D S Kapp, M K Cheung, K Osann, J Y Shin, D Cohn, P L Seid
Affiliations

The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients

J K Chan et al. Br J Cancer. .

Abstract

The aim of the study was to determine the impact of the absolute number and ratio of positive lymph nodes on the survival in node-positive endometrioid uterine cancer. Data were obtained from the National Cancer Institute Registry from 1988 to 2001. Analyses were performed using Kaplan-Meier and Cox proportional hazard methods. A total of 1222 women were diagnosed with stage IIIC-IV node-positive endometrioid corpus cancer. The 5-year disease-specific survival of women with 1, 2-5, and >5 positive nodes were 68.1, 55.1, and 46.1%, respectively (P<0.001). Increasing lymph node ratio, expressed as a percentage of positive nodes to total nodes identified (</=10, >10-</=50, and >50%), was associated with a decrease in survival from 77.3 to 60.7 to 40.9%, respectively (P<0.001). The absolute number of positive nodes and the lymph node ratio remained significant after adjusting for stage (IIIC vs IV) and the extent of lymphadenectomy (</=20 vs >20 nodes). On multivariate analysis, the absolute number of positive nodes and lymph node ratio were significant independent prognostic factors for survival. Increasing absolute number of positive nodes and lymph node ratio are associated with a poorer survival in women with node-positive uterine cancers. The stratification of node-positive uterine cancer for prognostic and treatment purposes warrants further investigation.

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Figures

Figure 1
Figure 1
Kaplan–Meier disease-specific survival of node-positive endometrioid uterine cancer based on (A) absolute number (1, 2–5, and >5) of positive nodes: 68.1, 55.1, and 46.1%; P<0.001, and (B) ratio of positive lymph nodes (⩽10, >10–⩽50, and >50%): 77.3, 60.7, and 40.9%; P<0.001.
Figure 2
Figure 2
Kaplan–Meier disease-specific survival based of stage IIIC (A and B) vs stage IV (C and D) disease by absolute number (A and C) and ratio (B and D) of positive lymph nodes.
Figure 3
Figure 3
Kaplan–Meier disease-specific survival based on extent of node dissection ⩽20 nodes (A and B) vs >20 nodes (C and D) disease by absolute number (A and C) and ratio (B and D) of positive lymph nodes.
See this image and copyright information in PMC

References

    1. Bando E, Yonemura Y, Taniguchi K, Fushida S, Fujimura T, Miwa K (2002) Outcome of ratio of lymph node metastasis in gastric carcinoma. Ann Surg Oncol 9: 775–784 - PubMed
    1. Berger AC, Sigurdson ER, LeVoyer T, Hanlon A, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG (2005) Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 23: 8706–8712 - PubMed
    1. Blythe JG, Edwards E, Heimbecker P (1997) Paraaortic lymph node biopsy: a twenty-year study. Am J Obstet Gynecol 176: 1157–1162;discussion 1162–5 - PubMed
    1. Bruner DW, Barsevick A, Tian C, Randall M, Mannel R, Cohn DE, Sorosky J, Spirtos NM (2006) Randomized trial results of quality of life comparing whole abdominal irradiation and combination chemotherapy in advanced endometrial carcinoma: a gynecologic oncology group study. Qual Life Res 16: 89–100 - PubMed
    1. Chan JK, Cheung MK, Huh WK, Osann K, Husain A, Teng NN, Kapp DS (2006) Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12 333 patients. Cancer 107: 1823–1830 - PubMed