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Case Reports
. 2007 Dec;9(6):514-7.
doi: 10.1016/j.jfms.2007.05.004. Epub 2007 Aug 1.

Eosinophilic leukaemia in a cat

Hassan Sharifi  1 , Seyed Mahdi Nassiri, Hossein Esmaelli, Javad Khoshnegah
Affiliations
Case Reports

Eosinophilic leukaemia in a cat

Hassan Sharifi et al. J Feline Med Surg. 2007 Dec.

Abstract

A 14-year-old female domestic shorthair cat was presented to Tehran University Veterinary Teaching Hospital for a persistent fever, anorexia, intermittent vomiting, weight loss and weakness. The main clinical signs were pale mucous membranes, dehydration and splenomegaly. The complete blood count and serum biochemistry tests revealed non-regenerative anaemia, thrombocytopenia and increased alkaline phosphatase (ALP) activity. An enzyme-linked immunosorbent assay (ELISA) test for feline leukaemia virus was negative. Blood film and bone marrow examination revealed a large number of immature eosinophils with variable sizes and numbers of faintly azurophilic granules. Cytochemical staining of blood film demonstrated 70% positive cells for ALP activity. Four percent CD34 positive cells were detected by flow cytometry. As eosinophilic leukaemia is difficult to identify by light microscopy, well-defined diagnostic criteria and the use of flow cytometry and cytochemical staining can improve the ability to correctly diagnose this type of leukaemia in cats.

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Figures

Fig 1.
Fig 1.
Wright–Giemsa stained blood film. (A) Feline eosinophils with characteristic rod-shaped granules. (B) Immature eosinophils and eosinophilic precursors in the peripheral blood. (C) and (D) Arrows indicate neutrophils among eosinophils in the peripheral blood. Scale bars, 5 μm in panels (A)–(C) and 10 μm in panel (D).
Fig 2.
Fig 2.
LAP staining of the peripheral blood. (A) Blood film demonstrated 70% positive cells for ALP activity (arrows). (B) “Immature eosinophils' and eosinophilic precursors' round-oval nuclei” with finely stippled chromatin and prominent nucleoli (arrowhead). Scale bars, 10 μm.
See this image and copyright information in PMC

References

    1. Borgfeldt C.B., Hansen B., Manthrope R. The hypereosinophilic syndrome. Report of a case with successful medical treatment following cardiac biopsy, Scandinavian Journal of Rheumatology 17, 1988, 51–54. - PubMed
    1. Brito-Babapulle F. Clonal eosinophilic disorders and the hypereosinophilic syndrome, Blood Review 11, 1997, 129–145. - PubMed
    1. Facklam N.R., Kociba G.J. Cytochemical characterization of feline leukemic cells, Veterinary Pathology 23, 1986, 155–161. - PubMed
    1. Finlay D. Eosinophilic leukaemia in the cat: a case report, Veterinary Record 116, 1985, 567. - PubMed
    1. Hendrick M. A spectrum of hypereosinophilic syndrome examplified by six cats with eosinophilic enteritis, Veterinary Pathology 18, 1981, 188–200. - PubMed

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