Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Aug;117(8):2030-2.
doi: 10.1172/JCI33032.

The legacy of the Philadelphia chromosome

Gary A Koretzky  1
Affiliations
Review

The legacy of the Philadelphia chromosome

Gary A Koretzky. J Clin Invest. 2007 Aug.

Abstract

The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered. This Review series includes contributions from individuals who performed critical experiments addressing some of the most important of these questions, reflecting the nearly 50 years of work inspired by Nowell's initial finding. The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Peter Nowell, discoverer of the Philadelphia chromosome, at the September 2006 symposium in his honor, along with Brian Druker, Owen Witte (top row), Carlo Croce, Mark Greene, and Tony Hunter (bottom row).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nowell P., Hungerford D. A minute chromosome in human chronic granulocytic leukemia. Science. 1960;132:1497. - PubMed
    1. Nowell P.C., Hungerford D.A. Chromosome studies on normal and leukemic human leukocytes. J. Natl. Cancer Inst. 1960;25:85–109. - PubMed
    1. Rowley J.D. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:290–293. - PubMed
    1. de Klein A., et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982;300:765–767. - PubMed
    1. Groffen J., et al. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984;36:93–99. - PubMed

MeSH terms