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. 2007 Aug 3;317(5838):660-3.
doi: 10.1126/science.1139952.

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

Meng-Qiu Dong  1 , John D Venable, Nora Au, Tao Xu, Sung Kyu Park, Daniel Cociorva, Jeffrey R Johnson, Andrew Dillin, John R Yates 3rd
Affiliations

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

Meng-Qiu Dong et al. Science. .

Abstract

DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.

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