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Review
. 2008 Jun;28(3):209-22.
doi: 10.1007/s10792-007-9099-9.

Graft failure IV. Immunologic mechanisms of corneal transplant rejection

Eva-Marie Chong  1 , M Reza Dana
Affiliations
Review

Graft failure IV. Immunologic mechanisms of corneal transplant rejection

Eva-Marie Chong et al. Int Ophthalmol. 2008 Jun.

Abstract

Corneal transplantation is the oldest and the most common form of solid tissue transplantation in humans. Immunologic graft rejection is one of the main causes of short and long-term graft failure. Rejection involves donor tissue recognition and destruction by allo-specific immune cells of the recipient. This review outlines (1) the immunobiology of transplantation, with reference to ocular immune privilege, (2) factors that confer "high-risk" status to a graft and (3) the pathophysiologic mechanisms of corneal transplant rejection.

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