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Comparative Study
. 2007 Aug;64(8):894-9.
doi: 10.1001/archpsyc.64.8.894.

Incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes mellitus

Hannu Juvonen  1 , Antti Reunanen, Jari Haukka, Maria Muhonen, Jaana Suvisaari, Ritva Arajärvi, Timo Partonen, Jouko Lönnqvist
Affiliations
Comparative Study

Incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes mellitus

Hannu Juvonen et al. Arch Gen Psychiatry. 2007 Aug.

Abstract

Context: Patients with schizophrenia have an increased risk of type 2 diabetes mellitus. However, very few studies have dealt with the association of type 1 diabetes and schizophrenia. Preliminary evidence points to a possible inverse association.

Objective: To investigate the incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes born in 1950 through 1959 in Finland.

Design: A cohort study of individuals born in 1950 through 1959 with a follow-up of 1969 through 1991.

Setting: Finland.

Patients: All individuals born in 1950 through 1959 with type 1 diabetes were identified through nationwide registers. The incidence of schizophrenia until 1992 among the total 1950-1959 cohort and in individuals with type 1 diabetes was calculated using information from 3 health care registers.

Main outcome measure: Incidence of schizophrenia.

Results: The incidence of schizophrenia was 0.21 per 10 000 person-years in the group with type 1 diabetes and 0.56 per 10 000 person-years in the group without type 1 diabetes (P < .001).

Conclusion: The incidence of schizophrenia is decreased in patients with type 1 diabetes.

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