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. 2007 Aug;6(2):99-104.
doi: 10.1016/j.cmet.2007.07.005.

A balance of lipid-sensing mechanisms in the brain and liver

Liora Caspi  1 , Penny Y T Wang, Tony K T Lam
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Free article

A balance of lipid-sensing mechanisms in the brain and liver

Liora Caspi et al. Cell Metab. 2007 Aug.
Free article

Abstract

Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.

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