doi: 10.1016/j.bbrc.2007.07.137.
Epub 2007 Jul 31.
Differences in (-)citronellal binding to various odorant receptors
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- PMID: 17681278
- DOI: 10.1016/j.bbrc.2007.07.137
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Differences in (-)citronellal binding to various odorant receptors
Biochem Biophys Res Commun.
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Abstract
To test the hypothesis that olfactory receptors (ORs) recognize different molecular features of odor molecules termed "odotypes", we studied receptor-ligand interactions of two human and two mouse ORs, recognizing (-)citronellal. Structurally similar receptors provide identical binding pockets (OLFR43, OR1A1, and OR1A2), and have comparable EC(50) values. Other ORs with lower sequence identity bind (-)citronellal in a different way, leading to different EC(50) values.
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