Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Oct;120(4):827-34.
doi: 10.1016/j.jaci.2007.05.046. Epub 2007 Aug 6.

H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12

Veronique Godot  1 , Michel Arock, Gilles Garcia, Francis Capel, Carine Flys, Michel Dy, Dominique Emilie, Marc Humbert
Affiliations

H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12

Veronique Godot et al. J Allergy Clin Immunol. 2007 Oct.

Abstract

Background: CXCL12, a constitutive chemokine (ligand of CXCR4 and CXCR7), is expressed in the skin and airway epithelium and plays a significant role in allergic airway diseases. The pleiotropic effects of CXCL12 are enhanced by cofactors specific to the target cell.

Objective: We hypothesized that histamine, a major mediator of allergic reactions, could interact with CXCL12 to promote human mast cell (MC) migration.

Methods: The chemotactic effects of CXCL12 alone or in combination with histamine were evaluated on human precursor and mature MCs by using in vitro migration assays.

Results: CXCL12 exerts a chemotactic activity on both precursor and fully mature MCs. Histamine and supernatants from IgE-activated MCs enhanced CXCL12 chemotactic activity on the precursor MC population. The synergy between histamine and CXCL12 was not observed with mature MCs, CD4(+) T cells, and monocytes. Inhibition of histamine receptors pharmacologically or with specific small interfering RNA (siRNA) indicated that synergy between histamine and CXCL12 required the H(4) receptor.

Conclusion: Histamine released by allergen-activated mature MCs might promote MC-rich allergic inflammation by enhancing recruitment of their precursors in tissues constitutively expressing CXCL12, including skin and airways.

Clinical implications: This work highlights a novel role of the H(4) receptor in the perpetuation of allergic responses and provides evidence for the utility of H(4) receptor antagonists in the treatment of allergic diseases.

PubMed Disclaimer

Publication types