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Review
. 2008;121(4):535-42.
doi: 10.1016/j.thromres.2007.06.002. Epub 2007 Aug 2.

Role of metalloproteinases in platelet function

María José Santos-Martínez  1 , Carlos Medina, Paul Jurasz, Marek W Radomski
Affiliations
Review

Role of metalloproteinases in platelet function

María José Santos-Martínez et al. Thromb Res. 2008.

Abstract

Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.

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