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. 2007 Jul;30(7):873-80.
doi: 10.1093/sleep/30.7.873.

Chronic insomnia as a risk factor for developing anxiety and depression

Dag Neckelmann  1 , Arnstein Mykletun, Alv A Dahl
Affiliations

Chronic insomnia as a risk factor for developing anxiety and depression

Dag Neckelmann et al. Sleep. 2007 Jul.

Abstract

Study objective: To study prospectively the relations of insomnia to the development of anxiety disorders and depression in a population-based sample.

Design: Cohort study based on data from 2 general health surveys of the adult population.

Setting: Two general health surveys in the adult population in Nord-Trøndelag County of Norway, HUNT-1 performed in 1984-6 and HUNT-2 in 1995-7

Participants: Participants without significant anxiety and depression in HUNT-1 were categorized according to the presence and absence of insomnia in the 2 surveys (N=25,130).

Measurements and results: Anxiety disorders and depression in HUNT-2 were assessed by the Hospital Anxiety and Depression Scale and analyzed using multivariate logistic regression analysis adjusted for age, gender, education, comorbid depression/anxiety, and history of insomnia. Anxiety disorders in HUNT-2 were significantly associated with the group with insomnia in HUNT-1 only (OR 1.6; 95% CI, 1.1-2.3), the group with insomnia in HUNT-2 only (OR 3.4; 95% CI, 3.1-3.8), as well as with the group with insomnia in both surveys (OR 4.9; 95% CI, 3.8-6.4). Depression in HUNT-2 was significantly associated with the group with insomnia in HUNT-2 only (OR 1.8; 95% CI, 1.6-2.0), but not with the groups with insomnia in HUNT-1 only or with insomnia in both surveys.

Conclusions: Only a state-like association between insomnia and depression was found. In addition to being a state marker, insomnia may be a trait marker for individuals at risk for developing anxiety disorders. Results are consistent with insomnia being a risk factor for the development of anxiety disorders.

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Figures

Figure 1
Figure 1
Flow Diagram of Sample Selection
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References

    1. Benca KM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49:651–68. - PubMed
    1. Wu JC, Bunney WE. The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry. 1990;147:14–21. - PubMed
    1. Thase ME, Buysse DJ, Frank E, et al. Which depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles. Am J Psychiatry. 1997;154:502–9. - PubMed
    1. Weitzman ED, Kripke DF, Goldmacher D, McGregor P, Nogeire C. Acute reversal of the sleep-waking cycle in man. Effect on sleep stage patterns. Arch Neurol. 1970;22:483–9. - PubMed
    1. Janowsky DS, el-Yousef MK, Davis JM, Sekerke HJ. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 1972;2:632–5. - PubMed