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. 2007 Sep;10(5):565-75.
doi: 10.1111/j.1467-7687.2007.00619.x.

Maturation of the long-latency auditory ERP: step function changes at start and end of adolescence

Dorothy V M Bishop  1 , Mervyn Hardiman, Ruth Uwer, Waldemar von Suchodoletz
Affiliations

Maturation of the long-latency auditory ERP: step function changes at start and end of adolescence

Dorothy V M Bishop et al. Dev Sci. 2007 Sep.

Abstract

The auditory event-related potential (ERP) is obtained by averaging electrical impulses recorded from the scalp in response to repeated stimuli. Previous work has shown large differences between children, adolescents and adults in the late auditory ERP, raising the possibility that analysis of waveform shape might be useful as an index of brain maturity. We reanalysed auditory ERPs from samples previously described by Albrecht, von Suchodoletz and Uwer (2000) and Uwer, Albrecht and von Suchodoletz (2002), using the intraclass correlation (ICC) as a global measure of similarity of an individual's waveform to a grand average comparison waveform for each age band. Three developmental periods were clearly distinguished: 5 to 12 years, 13 to 16 years, and adulthood. However, within each of these periods, there was no evidence of any developmental progression with age.

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Figures

Figure 1
Figure 1
Grand average auditory ERP from 21 adults studied by Albrecht et al. (2000). For each listener, the ERP was obtained by averaging responses to over 900 sinusoidal 1000 Hz tones, 175 ms in duration. Summary information about the generators for each peak is based on Velasco, Velasco and Velasco (1989), Näätänen (1992) and Ponton et al. (2000).
Figure 2
Figure 2
Grand average auditory ERPs for tones groups by age group at electrode Fz.
Figure 3
Figure 3
Topographic maps showing amplitudes of ERP at all electrodes for tone stimuli over the interval 48 to 328 ms post-onset.
Figure 4
Figure 4
Topographic maps showing amplitudes of ERP at all electrodes for syllable stimuli over the interval 48 to 328 ms post-onset.
Figure 5
Figure 5
Mean ICC over 0 to 552 ms in each age band, relative to normative waveforms from different age bands (x-axis) at nine electrodes. Simulations of comparable data by Bishop and McArthur (2005) gave estimates of .50, .69 and .72 as values corresponding to the 5%, 2.5% and 1% levels of significance (one-tailed).
Figure 6
Figure 6
Mean ICC over 100 to 228 ms for typically developing children in each age band, relative to normative waveforms from different age bands (x-axis) at nine electrodes. Simulations of comparable data by Bishop and McArthur (2005) gave estimates of .48, .53 and .66 as values corresponding to the 5%, 2.5% and 1% levels of significance (one-tailed).
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References

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    1. Bruneau N, Gomot M. Auditory evoked potentials (N1 wave) as indices of cortical development. In: Garreau B, editor. Neuroimaging in child neuropsychiatric disorders. Paris: Springer-Verlag; 1998. pp. 113–123.

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