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Review
. 2007 Oct;211(4):415-27.
doi: 10.1111/j.1469-7580.2007.00790.x. Epub 2007 Aug 7.

Contribution of endothelial cells to organogenesis: a modern reappraisal of an old Aristotelian concept

E Crivellato  1 , B Nico, D Ribatti
Affiliations
Review

Contribution of endothelial cells to organogenesis: a modern reappraisal of an old Aristotelian concept

E Crivellato et al. J Anat. 2007 Oct.

Abstract

It is well established that many tissue-derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article summarizes some of the recent advances in our understanding of the role of endothelial cells as effector cells in organ formation.

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