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. 2007 Aug 3:8:51.
doi: 10.1186/1471-2350-8-51.

The TCF7L2 locus and type 1 diabetes

Hui-Qi Qu  1 , Constantin Polychronakos
Affiliations

The TCF7L2 locus and type 1 diabetes

Hui-Qi Qu et al. BMC Med Genet. .

Abstract

Background: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D).

Methods: The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent.

Results: This study found no T1D association with, and no age-of-onset effect from rs7903146.

Conclusion: This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

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Figures

Figure 1
Figure 1
The statistical power of this study to detect a genetic association with the minor allele frequency of 0.303 at α = 0.05 level. X-axis: the OR value; Y-axis: the statistical power.
See this image and copyright information in PMC

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