Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Aug 3:8:51.
doi: 10.1186/1471-2350-8-51.

The TCF7L2 locus and type 1 diabetes

Hui-Qi Qu  1 , Constantin Polychronakos
Affiliations

The TCF7L2 locus and type 1 diabetes

Hui-Qi Qu et al. BMC Med Genet. .

Abstract

Background: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D).

Methods: The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent.

Results: This study found no T1D association with, and no age-of-onset effect from rs7903146.

Conclusion: This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The statistical power of this study to detect a genetic association with the minor allele frequency of 0.303 at α = 0.05 level. X-axis: the OR value; Y-axis: the statistical power.
See this image and copyright information in PMC

References

    1. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320–323. doi: 10.1038/ng1732. - DOI - PubMed
    1. Todd JA. Statistical false positive or true disease pathway? Nat Genet. 2006;38:731–733. doi: 10.1038/ng0706-731. - DOI - PubMed
    1. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med. 2006;355:241–250. doi: 10.1056/NEJMoa062418. - DOI - PMC - PubMed
    1. Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes. 2006;55:2640–2644. doi: 10.2337/db06-0355. - DOI - PubMed
    1. Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB. Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes. 2006;55:2645–2648. doi: 10.2337/db06-0643. - DOI - PubMed

Publication types

Substances