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. 2007 Aug 30;9(18):3519-21.
doi: 10.1021/ol0713537. Epub 2007 Aug 9.

N-heterocyclic carbene catalyzed ring expansion of 4-formyl-beta-lactams: synthesis of succinimide derivatives

Gong-Qiang Li  1 , Yi Li, Li-Xin Dai, Shu-Li You
Affiliations

N-heterocyclic carbene catalyzed ring expansion of 4-formyl-beta-lactams: synthesis of succinimide derivatives

Gong-Qiang Li et al. Org Lett. .

Abstract

N-heterocyclic carbene (NHC) has been employed as an efficient catalyst for ring expansion of 4-formyl-beta-lactams, allowing the facile synthesis of succinimide derivatives. This organocatalytic process features readily availability of the catalyst, low catalyst loading, and mild reaction conditions.

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