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. 2007 Jul;4(7):e235.
doi: 10.1371/journal.pmed.0040235.

South Africa's experience of the closure of the cellulose sulphate microbicide trial

Gita Ramjee  1 , Roshini Govinden, Neetha S Morar, Anthony Mbewu
Affiliations

South Africa's experience of the closure of the cellulose sulphate microbicide trial

Gita Ramjee et al. PLoS Med. 2007 Jul.

Abstract

The researchers who conducted the cellulose sulphate microbicide trial share the lessons they learned from the trial's early closure.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Global Phase IIb/III Microbicide Clinical Trials
Red circle: Carraguard. Sponsored by Population Council. Phase III study of the efficacy and safety of the microbicide Carraguard in preventing HIV seroconversion in women. Blue cross: 2% and 0.5% PRO2000. Sponsored by Microbicide Development Programme. A phase III, multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the effectiveness and safety of 0.5% PRO2000 and 2% PRO2000 gels for the prevention of vaginally acquired HIV infection. Yellow cross: BufferGel and 0.5% PRO2000. Sponsored by US National Institutes of Health. HPTN 035: Phase II/IIb safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 gel (P) for the prevention of HIV infection in women. Green star: Cellulose sulphate—East and Southern Africa. Sponsored by CONRAD. Randomised controlled trial of 6% cellulose sulphate gel and the effect on vaginal HIV transmission. Green star: Cellulose sulphate—Nigeria. Sponsored by Family Health International. Phase III trial of cellulose sulphate for HIV prevention. Pink box: C31G (SAVVY). Sponsored by Family Health International. Phase III trial of SAVVY in Ghana and Nigeria.
See this image and copyright information in PMC

References

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