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. 2007 Aug;77(2):261-5.

Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys

William E Collins  1 , Joann S Sullivan, Patrice Hall, Trenton K Ruebush 2nd, Allison Williams, Katharine K Grady, Amy Bounngaseng, Douglas Nace, Tyrone Williams, Curtis Huber, G Gale Galland, John W Barnwell, James J Sullivan
Affiliations
  • PMID: 17690397

Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys

William E Collins et al. Am J Trop Med Hyg. 2007 Aug.

Abstract

A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.

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