Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Sep;6(9):746-62.
doi: 10.1038/nrd2361.

Translational research in medication development for nicotine dependence

Caryn Lerman  1 , Mark G LeSage, Kenneth A Perkins, Stephanie S O'Malley, Steven J Siegel, Neal L Benowitz, William A Corrigall
Affiliations
Review

Translational research in medication development for nicotine dependence

Caryn Lerman et al. Nat Rev Drug Discov. 2007 Sep.

Abstract

A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the development of new medications.

PubMed Disclaimer

Publication types

LinkOut - more resources