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Comparative Study
. 2007 Dec;30(6):244-9.
doi: 10.1007/s10753-007-9043-1. Epub 2007 Aug 10.

The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)

Mustafa Sahin  1 , Murat Cakir, Fatih Mehmet Avsar, Ahmet Tekin, Tevfik Kucukkartallar, Mehmet Akoz
Affiliations
Comparative Study

The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)

Mustafa Sahin et al. Inflammation. 2007 Dec.

Abstract

Purpose: The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.

Materials and methods: Rats were assigned to five groups: Group 1: Control. Group 2: chitin layers were used. Group 3: Na-hyaluronate / carboxymethylcellulose layers were used. Group 4: Na-hyaluronate gel was poured into the abdomen. Group 5: methylprednisolone was injected. The adhesion frequency and grade were scored according to Granat. Blood was taken for Hb, AST, BUN and albumin levels determination.

Findings: The adhesion frequencies (right and left) and grades were as follow in Groups; I: 82%, 91%, 2.63 +/- 1.22; II: 8.3%, 25%, 0.58 +/- 0.66; III: 17%, 33%, 1.08 +/- 1.08; IV: 50%, 58%, 1.41 +/- 1.44; V: 50%, 42%, 1.41 +/- 1.50. The adhesion phase in all study groups was found significantly low compared to control group, p < 0.05. No difference was observed among serologic and hematological parameters in all groups.

Conclusion: All the materials used significantly lowered the adhesion frequency and grade.

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