Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Apr;67(2):131-3.

[Human African trypanosomiasis: involvement of host genetics]

[Article in French]
D Courtin  1 , A Garcia
Affiliations
  • PMID: 17691429
Review

[Human African trypanosomiasis: involvement of host genetics]

[Article in French]
D Courtin et al. Med Trop (Mars). 2007 Apr.

Abstract

Two genetic epidemiological studies were carried out in the Ivory Coast and Democratic Republic of Congo to assess the role of human genetic diversity in susceptibility to human African trypanosomiasis (HAT). Findings showed that four single DNA polymorphisms located on genes coding for cytokines were correlated with a variable risk for development of the disease. Whereas presence of the rare A and T alleles for IL10 592 C/A and IL6 4339 C/T polymorphisms appeared to protect against HAT, presence of the T allele and AA genotype for IL1 5417 C/T and TNFalpha-308 G/A polymorphisms were correlated with an increase in HAT risk. These results will improve understanding of the host-parasite interaction and, ultimately, assist the development of new therapeutic and prophylactic tools.

PubMed Disclaimer