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. 2007 Oct 1;17(19):5419-22.
doi: 10.1016/j.bmcl.2007.07.027. Epub 2007 Jul 21.

Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines

Ahmed Kamal  1 , S Kaleem Ahmed, K Srinivasa Reddy, M Naseer A Khan, Rajesh V C R N C Shetty, B Siddhardha, U S N Murthy, Inshad Ali Khan, Manoj Kumar, Sandeep Sharma, Anshu Beulah Ram
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Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines

Ahmed Kamal et al. Bioorg Med Chem Lett. .

Abstract

In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities. One of the compounds 2f has shown good in vitro antimycobacterial activity. All the synthesized compounds have shown moderate to good antibacterial activity.

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