Review
doi: 10.1016/j.cell.2007.07.028.
A "reductionist" view of cardiomyopathy
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- PMID: 17693248
- DOI: 10.1016/j.cell.2007.07.028
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Review
A "reductionist" view of cardiomyopathy
Cell.
.
Free article
Abstract
Oxidative stress due to the generation of reactive oxygen species has been implicated in many diseases. Rajasekaran et al. (2007) now make the surprising discovery that its counterpart "reductive stress," caused by an increase in reduced glutathione, contributes to cardiomyopathy triggered by protein aggregation.
Comment on
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Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.Cell. 2007 Aug 10;130(3):427-39. doi: 10.1016/j.cell.2007.06.044. Cell. 2007. PMID: 17693254 Free PMC article.
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