Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2007 Aug 16;55(4):539-41.
doi: 10.1016/j.neuron.2007.07.033.

Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane

Diego Varela  1 , Gerald W Zamponi
Affiliations
Free article
Comment

Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane

Diego Varela et al. Neuron. .
Free article

Abstract

Calcium influx via L-type (Cav1.2 and Cav1.3) calcium channels is tightly regulated to ensure optimal intracellular calcium levels. Although much is known about acute modulation of these channels by second messengers, the mechanisms that control their trafficking to and from the plasma membrane remain poorly understood. In this issue of Neuron, Green and colleagues demonstrate that the opening of L-type calcium channels results in negative feedback regulation due to their calcium-dependent internalization.

PubMed Disclaimer

Comment on

LinkOut - more resources