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. 2007 Nov-Dec;29(6):634-41.
doi: 10.1016/j.ntt.2007.07.003. Epub 2007 Jul 14.

Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats

Josephine M Johns  1 , Matthew S McMurray, Vivian E Hofler, Thomas M Jarrett, Christopher L Middleton, Deborah L Elliott, Raessa Mirza, Amber Haslup, Jay C Elliott, Cheryl H Walker
Affiliations

Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats

Josephine M Johns et al. Neurotoxicol Teratol. 2007 Nov-Dec.

Abstract

Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams and prenatally exposed to either cocaine or control conditions were tested for pup-induced maternal behavior at postnatal days 28 and 60. We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure.

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