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Review
. 2007 Nov-Dec;39(3):336-9.
doi: 10.1016/j.bcmd.2007.06.009. Epub 2007 Aug 14.

MN1, a novel player in human AML

Gerard C Grosveld  1
Affiliations
Review

MN1, a novel player in human AML

Gerard C Grosveld. Blood Cells Mol Dis. 2007 Nov-Dec.

Abstract

The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Upregulation is invariantly associated with inv(16) AML but is also found in other AML subtypes. Overexpression of this gene is also associated with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In this short review, I will discuss the role of MN1 in myeloid leukemia.

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Figures

Figure 1
Figure 1
Model for MN1 function in myeloid cells. A) Via p300/CBP MN1 is recruited to, and regulates the transcriptional activity of RAR/RXR and VDR/RXR heterodimers affecting the differentiation of myeloid progenitors via up- (a), or downregulation (b) of target genes. MN1 can also be recruited to other transcription factors (X) that bind p300/CBP, again affecting transcription of target genes. B) MN1 might also bind directly to transcription factors (Y), affecting the transcription of target genes. The interaction with Y might also be indirect, i.e. via another interacting protein than p300/CBP (not indicated).
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