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Review
. 2006 May;1(3):404-14.
doi: 10.2215/CJN.00270106. Epub 2006 Apr 19.

Mechanisms and role of HLA and non-HLA alloantibodies

Kathryn J Tinckam  1 , Anil Chandraker
Affiliations
Review

Mechanisms and role of HLA and non-HLA alloantibodies

Kathryn J Tinckam et al. Clin J Am Soc Nephrol. 2006 May.

Abstract

The role of alloantibodies against HLA and non-HLA targets is becoming increasingly recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes. This review discusses the antigenic targets, the mechanisms of T and B cell activation that result in the production of antibody, the complement cascade, methods of antibody detection, and the evidence that alloantibody-mediated mechanisms are active in acute and chronic rejection.

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